Publications

Publications AMC/Hep-Art research group bioartificial liver

Geert A.A. Nibourg,  Robert A.F.M. Chamuleau,  Thomas M. van Gulik, Ruurdtje Hoekstra, Proliferative human cell sources applied as biocomponent in a bioartificial liver: a review. Expert Opinion on Biol Ther. 2012;12(7): 905-921.

Geert A.A. Nibourg, Robert A.F.M. Chamuleau, Tessa V. van der Hoeven, Martinus A.W. Maas, Mariette T Ackermans, Ronald P.J. Oude Elferink, Thomas M. van Gulik, Ruurdtje Hoekstra. Liver progenitor cell line HepaRG differentiated in a bioartificial liver effectively supplies liver support to rats with acute liver failure. PlosOne 2012; 7(6):e38778.

Wlodzimirow K.A., Eslami S., Abu-Hanna A., Nieuwoudt M. Chamuleau R.A.F.M. Acute liver failure-what is it? Hepatology 2012; 55(4): 1306-1307. DOI: 10.1002/hep.25519.

Kama A. Wlodzimirow, Saeid Eslami, Ameen Abu-Hanna, Martin Nieuwoudt, Robert A.F.M.Chamuleau Acute liver failure – One disease, more than 40 definitions in evaluation studies. Alimentary  Pharmaceutical Therapeutics, 2012 ;35: 1245-1256.

Kama A. Wlodzimirow,Saeid Eslami,Ameen Abu-Hanna,Martin Nieuwoudt, Robert A.F.M. Chamuleau, A systematic review on prognostic indicators of Acute Liver Failure and their predictive value for poor outcome. British Med Bulletin, 2012 submitted

Ruurdtje Hoekstra, Geert A.A. Nibourg, Tessa V. van der Hoeven, Mariëtte T. Ackermans, Theodorus B.M. Hakvoort, Thomas M. van Gulik, Ronald P. Oude Elferink, Robert A.F.M. Chamuleau The effect of rat acute-liver-failure plasma on HepaRG cells. IJAO 2012, in press

Geert A.A. Nibourg, Ruurdtje Hoekstra,Tessa V. van der Hoeven, Mariëtte T. Ackermans, Theodorus B.M. Hakvoort, Thomas M. van Gulik, Robert A.F.M. Chamuleau. Effects of acute-liver-failure-plasma exposure on hepatic functionality of HepaRG-AMC-Bioartificial Liver. Liver Transplantation, 2012 submitted

Kama Wlodzimirow, Saeid Eslami, Martin Nieuwoudt, Ameen Abu-Hanna, Robert Chamuleau A Systematic Review on markers of human Acute on Chronic Liver Failure and their predictive value for mortality. Liver International 2012 Mar 19.

Ruurdtje Hoekstra, Geert A.A.Nibourg, Tessa V. van der Hoeven, Gabrielle Plomer, Jurgen Seppen, Mariëtte T. Ackermans3, Sandrine Camus, Wim Kulik, Thomas M. van Gulik, Ronald P. Oude Elferink, Robert A.F.M. Chamuleau. Drug metabolism and bile acid production of HepaRG cells in the AMC-Bioartificial Liver in absence of DMSO. Toxicology and Applied Pharmacology, 2012 submitted.

Ruurdtje Hoekstra, Geert A.A.Nibourg, Tessa V. van der Hoeven, Mariëtte T. Ackermans, Theodorus B.M. Hakvoort, Thomas M. van Gulik, Wouter H. Lamers, Ronald P. Oude Elferink, Robert A.F.M. Chamuleau.The HepaRG cell line is suitable for bioartificial liver application. Int J Biochem Cell Biol 2011; 43: 1483-1489. DOI 0.1016/j.biocel.2011.06.011

Geert A.A. Nibourg, Maarten T. Huisman, Tessa V. van der Hoeven, Thomas M. van Gulik, Robert A.F.M. Chamuleau, Ruurdtje Hoekstra. Stable overexpression of pregnane X receptor in HepG2 cells increases its potential for bioartificial liver application. Liver Transplantation, 2010; 16(9): 1075-85. PMID:20818746

Geert A.A. Nibourg, Justin D. Boer, Tessa V. van der Hoeven, Mariëtte T Ackermans, M.S., Thomas M. van Gulik, , Robert A.F.M. Chamuleau,  Ruurdtje Hoekstra. Perfusion flow rate and performance of the HepaRG-AMC-bioartificial liver. Biotechnology Bioengineering 2012; DOI 10.1002/bit.24586

Giuseppe Di Nicuolo, Alba D’Alessandro, Barbara Andria, Vincenzo Scuderi, Michele Scognamiglio, Angela Tammaro, Antonio Mancini, Ernesto Di Florio, Adele Bracco, Fulvio Calise, Robert A.F.M. Chamuleau. Long-term absence of PERV infection in chronically immunosuppressed patients after treatment with the porcine cell based AMC-bioartificial liver and in healthcare workers exposed to porcine materials during its preparation and application. Xenotransplantation, 2010; 17: 431-439. doi: 10.1111/j.1399-3089.2010.00617.x.

Geert A.A. Nibourg, Maarten T. Huisman, Tessa V. van der Hoeven, Thomas M. van Gulik, Robert A.F.M. Chamuleau, Ruurdtje Hoekstra. Stable overexpression of pregnane X receptor in HepG2 cells increases its potential for bioartificial liver application. Liver Transplantation, 2010, 16(9): 1075-85. PMID: 20818746

Andria B, , Bracco A, Cirino G, Chamuleau RAFM. Liver Cell Culture Devices. Cell Medicine-Cell Transplantation Part B. 2010; 16: 55-70

Chamuleau RAFM, The future of bioartificial liver support. World J Gastroenterol. Surgery 2009; 1(1): 21-25. PMID: 21160791

Tanja Deurholt, Niek P. van Til, Aniska A. Chhatta, Lysbeth ten Bloemendaal, Ruth Schwartlander, Catherine Payne, John Plevris, Igor M. Sauer, Robert A.F.M. Chamuleau, Ronald P.J. Oude Elferink, Jurgen Seppen, Ruurdtje Hoekstra. Novel immortalized Human Fetal Liver Cell Line, cBAL111, has the Potential to fully differentiate into functional Hepatocytes. BMC Biotechnology 2009;9:89. PMID: 19845959

Poyck PP, Hoekstra R, Vermeulen JL, van Wijk AC, Chamuleau RA, Hakvoort TB, van Gulik TM, Lamers WH. Expression of glutamine synthase and carbamyl-phosphate synthase I in a bioartificial liver: markers for the development of zonation in vitro. Cells, Tissues and Organs 2008: 188 (3): 259-69. PMID: 18354250

Paul P.C. Poyck, Guy Mareels, Ruurdtje Hoekstra, Albert C.W.A. van Wijk, Tessa V. van der Hoeven, Thomas M. van Gulik, Pascal R. Verdonck, Robert A.F.M.Chamuleau . Enhanced oxygen availability improves liver-specific functions of the AMC bioartificial liver, Artificial Organs, 2008; 32(2): 116-126 PMID: 18005273

Paul P.C Poyck, Albert C.W.A. van Wijk, Tessa V. van der Hoeven, Dirk R. de Waart, Robert A.F.M. Chamuleau, Thomas M. van Gulik, Ronald P.J. Oude Elferink, Ruurdtje Hoekstra . Evaluation of a new immortalized human fetal liver cell line (cBAL111) for application in bioartificial liver. J of Hepatol, 2008; 48(2): 266-275. PMID: 18093687

Paul P.C Poyck; Ruurdtje Hoekstra; Aniska Chhatta; Lysbeth ten Bloemendaal; Albert C.W.A. van Wijk, Daniele Galavotti, Thomas M. van Gulik, Robert A.F.M. Chamuleau, Time-related analysis of metabolic liver functions, cellular morphology and gene expression of hepatocytes cultured in the AMC-BAL, Tissue Engineering 2007; 13(6): 1235-46. PMID: 17518723

Poyck, P.P.C., Pless, G., Hoekstra, R., Roth, S., Van Wijk, A.C.W.A., Schwartlander, R., Van Gulik, T.M., Sauer, I.M. and Chamuleau, R.A.F.M. First in vitro Comparison of Two Bioartificial Liver Support Systems: MELS CellModule and AMC-BAL. Int. J. Artif. Organs, 2007; 30(3): 183-191 PMID: 17417756

Deurholt, T., Ten Bloemendaal, L., Chhatta, A., Van Wijk, A.C.W.A., Seppen, J., Oude Elferink, R.P.J., Chamuleau, R.A.F.M. and Hoekstra, R. In vitro functionality of human fetal liver cells and clonal derivatives under proliferative conditions. Cell Transplant., 2006; 15, 811-822. PMID 17269451

Guy Mareels, PPC Poyck, S. Eloot, D.S. R.A.F.M. Chamuleau, P.R. Verdonck. Three-dimensional numerical modeling and computational fluid dynamics simulations to analyze and improve oxygen availability in the AMC bioartificial liver. Ann. Biomed. Eng. 2006; 34(11): 1729-1744. PMID 17031599

van de Kerkhove MP, Hoekstra R, van Nooijen FC, Spoelstra FO, Doorschodt BM, van Wijk AC, Poyck PP, Chamuleau RA, van Gulik TM. Subnormothermic preservation maintains viability and function in a porcine hepatocyte culture model simulating bioreactor transport. Cell Transplant. 2006;15(2):161-8.  PMID 16719049

Ruurdtje Hoekstra, Tanja Deurholt, Lysbeth ten Bloemendaal, Mireille Desille, Albert C.W.A. van Wijk, Bruno Clement, Ronald P.J. Oude Elferink, Thomas M. van Gulik, Robert A.F.M. Chamuleau Assessment of in vitro applicability of reversibly immortalised NKNT-3 cells and clonal derivatives. Cell transplantation. 2006; 15: 423-433. PMID 16015572

Robert AFM Chamuleau, Paul PC Poyck, Maarten-Paul van de Kerkhove. Bioartificial liver: its pro’s and cons. Therapeutic Apheresis and Dialysis, 2006; 10(2):168-74. PMID 16684219

Robert A.F.M. Chamuleau, Tanja Deurholt, Ruurdtje Hoekstra. Which are the right cells to be used in a bio-artificial liver? Metabolic Brain Research 2005; 20(4):327-335. PMID 16382343

Di Nicuolo, G. Van de Kerkhove, M.P., Hoekstra, R., Amoroso, P., Battisti, S., Starace, M., Di Florio, E., Scuderi, V., Scala, S., Bracco, A., Manzini, A., Chamuleau, R.A.F.M. and Calise, F. No evidence of in vitro and in vivo porcine endogenous retrovirus infection after plasmapheresis through the AMC-Bioartificial liver. Xenotransplant.,2005; 12: 286-92. PMID 15943777

Van de Kerkhove, M-P., Poyck, P.P.C., Van Wijk, A.C.W.A., Galavotti, D. Hoekstra, R., Van Gulik, T.M., and Chamuleau, R.A.F.M. Assessment and improvement of liver specific function of the AMC-bioartificial liver. Int. J. Artif. Organs, 2005;28: 617-30. PMID 16015572

Hoekstra, R., Deurholt, T., Poyck, P.P.C., Ten Bloemendaal, L. and Chhatta, A.A. Increased reproducibility of quantitative reverse transcriptase-PCR. Anal. Biochem.,2005; 340/2: 376-9. PMID 15840513

Van de Kerkhove, M-P., Poyck, P.P.C., Deurholt, T., Hoekstra, R., Chamuleau, R.A.F.M. and Van Gulik, T.M. Liver support therapy; An overview of the AMC-bioartificial liver research. Digestive Surgery, 2005; 22: 254-64. PMID 16174982

Poyck, P.P.C., Hoekstra, R., Van Wijk, A.C.W.A., Ten Bloemendaal, L., Chamuleau, R.A.F.M and Van Gulik, T.M. Mild hypothermic preservation for transport purposes of the AMC-bioartificial liver charged with porcine hepatocytes. Transplantation.2005; 80: 1153-60. PMID 16314779

Van de Kerkhove M-P, Germans MR, Deurholt T, Joziasse DH, van Wijk ACWA, van Gulik TM, Chamuleau RAFM, Roos A. Evidence for Galalfa (1-3)Gal expression on primary porcine hepatocytes: implications for bioartificial liver systems. J Hepatol 2005; 42: 541-547. PMID 15763340

Van de Kerkhove M-P, Hoekstra R. Chamuleau RAFM, van Gulik TM. Clinical application of bioartificial liver support systems. Annals of Surgery, 2004; 240(2): 216-230. PMID 15273544

Chamuleau RAFM. Artificial liver support in the third millennium. Artif Cells Blood Substit Immobil Biotechnol 2003; 31(2): 117-126. PMID 12751830

Van de Kerkhove M-P, Chamuleau RAFM, van Gulik TM. Clinical application of bioartificial liver support systems. In: Encephalopathy and Nitrogen Metabolism in Liver Failure. Eds E.A. Jones, AJ Meijer, RAFM Chamuleau. Kluwer Academic Publishers, Dordrecht/Boston/London. 2003; p389-406.

Abrahamse SL, van Runnert Heimel P, Hartman RJ, Chamuleau RAFM, van Gulik TM. Induction of necrosis and DNA fragmentation during hypothermic preservation of hepatocytes in UW, HTK, and Celsior solutions. Cell Transplantation 2003; 12: 59-68. PMID 12693665

Maarten-Paul van de Kerkhove, Ernesto Di Florio, Vincenzo Scuderi, Antonio Mancini, Antonello Belli, Adele Bracco, Daniela Scala, Simona Scala, Laura Zeuli, Giuseppe Di Nicuolo, P. Amoroso, Fulvio Calise, Robert A.F.M. Chamuleau , Bridging a patient  with acute liver failure to liver transplantation by the AMC-Bioartificial liver. Cell Transplantation 2003;12: 563-568. PMID 14579924

Maarten-Paul van de Kerkhove, Ruurdtje Hoekstra, Thomas M. van Gulik, Robert A.F.M. Chamuleau. Large animal models of fulminant hepatic failure in liver support research. Biomaterials 2004; 25: 1613-1625 PMID 14697863

Sosef MN, Van De Kerkhove MP, Abrahamse SL, Levi MM, Chamuleau RA, Van Gulik TM. Blood coagulation in anhepatic pigs: effects of treatment with the AMC-bioartificial liver. Thromb Haemost. 2003 ;1(3):511-5. PMID 12871459

Sosef MN, Abrahamse LS, van de Kerkhove MP, Hartman R, Chamuleau RA, van Gulik TM. Assessment of the AMC-bioartificial liver in the anhepatic pig. Transplantation 2002;73(2):204-209. PMID 11821731

Maarten-Paul van de Kerkhove, Ernesto Di Florio, Vincenzo Scuderi, Antonio Mancini, Antonello Belli, Adele Bracco, Mario Dauri, Giuseppe Tisone, Giuseppe Di Nicuolo, Pietro Amoroso, Alessandro Spadari, Guerino Lombardi, Ruurdtje Hoekstra, Fulvio Calise, Robert A.F.M. Chamuleau . Phase I clinical trial with the AMC Bioartificial liver. Int J Artif Organs, 2002;25: 950-959.  PMID 12456036

S.L. Abrahamse, M.-P. van de Kerkhove, M.N. Sosef, R. Hartman, R.A.F.M. Chamuleau and T.M. van Gulik. Treatment of acute liver failure in pigs reduces hepatocyte function in a bioartificial liver support system. Int J Artif Organs 2002; 25: 966-97. PMID 12456038

Hoekstra R, Chamuleau RAFM. Recent developments on human cell lines for the bioartificial liver. Int J Artif Organs 2002;25/3:182-191. PMID 11999190

M.N. Sosef, L.S.L. Abrahamse, M-P van de Kerkhove, R. Hartman, R.A.F.M. Chamuleau, T.M. van Gulik. Assessment of the AMC-Bioartificial liver in the anhepatic pig. Transplantation 2002;73/2:204-209. PMID 11821731

Chamuleau RAFM, Flendrig LM. The bioartificial liver of the Academic Medical Centre at Amsterdam. In The Hepatocyte Review, Eds MN Berry and A.M Edwards, Kluwer Academic Publishers, 2000; 575-583.

Chamuleau RAFM, Flendrig LM. Future of the artificial liver in front of the next millennium. In : IHPBA, Budapest 1999. Eds Lajos Flautner, Peter K Kupcsulik, Imre Rozsa, Monduzi Editore, Budapest, 1999, p109-114

Flendrig LM, Calise F, Di Florio E, Mancini A, Ceriello A, Santaniello W, Mezza E, Sicoli F, Belleza G, Bracco A, Cozzolino S, Scala D, Mazzone M, Fattore M, Gonzales E,Chamuleau RAFM. Significantly improved survival time in pigs with complete liver ischemia treated with a novel bioartificial liver. Int J Artif Organs 1999; 22:701-708. PMID 10585135

Flendrig LM, Chamuleau RAFM, Maas MAW et al. In vivo evaluation of a novel bioartificial liver in rats with complete liver ischemia: treatment efficacy and species-specific alpha GST as a first attempt to monitor hepatocyte viability. J of Hepatology, 1999; 30(2):311-320. PMID 10068112

Flendrig LM, Sommeijer D, Ladiges NCJJ, te Velde AA, Maas MAW, Jörning GGA, Daalhuisen J, Chamuleau RAFM. Commercially available media for flushing extracorporeal bioartificial liver systems before clinical application: an in vitro comparative study in two and three dimensional porcine hepatocyte cultures. Internat J Artif Organs. 1998;21/8: 467-472. PMID 9803349

Flendrig LM, Maas MAW, Daalhuisen J, Ladiges NCJJ, La Soe JW, Te Velde AA, Chamuleau RAFM. Does the extent of the culture time of primary hepatocytes in a bioreactor affect the treatment efficacy of a bioartificial liver? Int J Artif Organs 1998;21(9):542-547.

Chamuleau RAFM, Te velde AA, 1997. Possible immunological problems. By using xenogeneic liver cells as bioartificial liver support. In: Crepaldi G, Demetriou AA, Muraca M, Editors . Bioartificial liver support systems. The critical issues. Rome: CIC Edizioni Internazionali, p82-85.

Flendrig LM., la Soe JW., Jorning GGA., Steenbeek A., Ladiges NCJJ., te Velde AA., Chamuleau RAFM, In vitro evaluation of a novel bioartificial liver system based on a spirally nonwoven polyester matrix for high density hepatocyte culture as small aggregates. J Hepatol 1997; 26:1379-1392. PMID 9210627

Flendrig LM, te Velde AA, Chamuleau RAFM. Semipermeable hollow fiber membranes in hepatocyte bioreactors: a prerequisite for a successful bioartificial liver? Artif organs 1997; 21 (11): 1177-1181. PMID 9384322

Flendrig LM, Di Florio E, Mancini A, et al 1997. In vivo evaluation of a novel bioartificial liver in a surgical model of acute liver failure in the pig. Preliminary results. In: Bioartificial liver support systems, the critical issues. Eds G. Crepaldi, A.A. Demetriou, M. Muraca CIC Edizioni Internazionali Rome; p 42-47.

Te Velde AA, Flendrig LM, Ladiges NCJJ, Chamuleau RAFM, Possible Immunological problems of  bioartificial liver support. Int J Artif Organs 1997; 20 (8):418-421. PMID 9323503

te Velde AA, Flendrig LM, Ladiges NC, Chamuleau RA. Immunological consequences of the use of xenogeneic hepatocytes in a bioartificial liver for acute liver failure. Int J Artif Organs. 1997;20(4):229-33. PMID: 9195241

Chamuleau RAFM., Animal models of hepatic encephalopathy. Seminars in liver disease1996; 16(3):265-270. PMID 898912